The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Richard Gere’s 24-Year-Old Son Caused a Sensation on the Red Carpet, and People Say He’s More Handsome Than His Father
Richard Gere is one of those actors who loves to keep his personal life private. However, he recently made a spectacular appearance on the red carpet. The 74-year-old actor appeared with his 41-year-old wife and 24-year-old son, Homer. The young man immediately attracted everyone’s attention.
The father-son duo looked exceptionally dapper in their elegant black suits, complemented by matching bow ties and crisp white dress shirts. Radiating charm, they delighted cameras with their warm smiles and shared a heartfelt embrace.
Fans online were surprised by how handsome Homer looked. One person gushed, saying, “Wow, his son is so good-looking!” Another described him as a “Beautiful guy!” A third person observed, “His son is more handsome than Dad […]”
Homer was born in February 2000, and he shared his name with his grandfather, Richard Gere’s dad, who passed away in 2023 at 100 years old. His mother is Gere’s second ex-wife, model and actress Carey Lowell.
Homer Gere attended Hackley School in Tarrytown, New York, and later graduated from Brown University in May 2024 with a Bachelor of Arts in psychology and visual art, as per his LinkedIn profile. Since September 2022, he has been working as a research assistant in the therapeutic neuroscience lab at an Ivy League School of Public Health.
In a March 2024 interview with Vanity Fair Spain, Richard Gere mentioned that Homer Gere struggles to comprehend his father’s fame. Richard said, “It’s hard for him to see me on screen because, even when I play extreme characters, I’m still his father, making it hard for him to get into the story.”
Richard also revealed that Homer is beginning to follow in his footsteps by exploring his acting and musical talents. “He has just started acting and seems to enjoy it,” Richard noted. “He’s been writing and directing small films, giving us a new shared interest.”
Moreover, Richard emphasized the importance of his children learning to play an instrument. Homer initially chose the piano as a child but eventually quit. He then switched to drums, which he also didn’t stick with for long. However, a few years ago, he began playing in his own band in college and is now a vocalist in a punk band.
Another celebrity child who attracts a lot of attention is Angelina Jolie and Brad Pitt’s daughter, Shiloh. She has taken social media by storm with her dancing.
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