The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.

On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.

Fully regrown frontal teeth in ferrets
The next steps

Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
She rose to fame on Dallas, take a moment to prepare yourself for her appearance today at 84

Linda Gray became a household name thanks to her role as Sue Ellen Ewing on the beloved soap opera Dallas. Over the course of more than 300 episodes, she not only showcased her incredible talent but also faced numerous personal challenges along the way. Today, at 84 years old, Gray continues to shine.
Throughout the history of film and television, we have witnessed remarkable performances by countless actors. Some portrayals resonate so deeply that it’s hard to imagine anyone else in the role. For instance, who could envision Little House on the Prairie without Michael Landon as Charles Ingalls or Mary Poppins without Dick Van Dyke as Bert? Similarly, Linda Gray’s portrayal of Sue Ellen is irreplaceable, and fans of the show are grateful she was cast in such a pivotal role.

Gray’s life has been nothing short of extraordinary, resembling a roller coaster filled with ups and downs. She has confronted life-threatening illnesses, addiction, and a challenging marriage. Despite these adversities, she has always emerged stronger, committed to making the most of her life and career.
Starring alongside Larry Hagman and Patrick Duffy on Dallas, Gray recently opened up about her experiences working with Hagman and the dynamic chemistry they shared on set.

Born on September 12, 1940, in Santa Monica, California, Gray faced a significant challenge in her childhood when she was diagnosed with polio. Her grandfather had also contracted the virus, leaving her family in distress. However, Linda maintained a surprisingly optimistic outlook during her own diagnosis. “They didn’t know what it was when he was 17, and he was always in a wheelchair”, she recalled. “When I was diagnosed, everyone went crazy in my family, but I wasn’t. I thought I could have a wheelchair like Grandpa.”
Growing up in Culver City, California, where her father owned a watchmaker shop, Linda was drawn to the performing arts from a young age. She often entertained her neighbors and even starred as Cinderella in a school production at Notre Dame Academy in Los Angeles.

While her father provided a stable presence, he was emotionally distant. As Gray noted in her 2015 memoir, The Road to Happiness Is Always Under Construction, “He was just kind of there, like a piece of furniture”, and emotional discussions were off-limits. In contrast, her mother, Marge, a former artist and ballerina, struggled with alcoholism, leaving Linda and her sister to take charge of the household. “She wasn’t mean, she was just blurred, in her own world”, Gray wrote. This upbringing inspired Linda to pursue a different path, determined to avoid her mother’s fate.

With dreams of a career in medicine initially, Gray soon shifted her focus to acting, influenced by the Hollywood landscape surrounding her. She spent her teenage years modeling for various companies and airlines.
At 21, Linda married photographer Edward Lee Thrasher, but the marriage became a struggle. Her aspirations took a backseat as she became a wife and mother, welcoming son Jeff in 1960 and daughter Kehly six years later. Linda felt emotionally neglected, describing the marriage as “cold” and ultimately deciding to leave after 21 years.
Despite her husband’s disapproval of her pursuing acting, Gray took the plunge and began landing television commercials. She had minor roles in films like Under the Yum Yum Tree and Palm Springs Weekend but hit the jackpot when, at 27, she became Anne Bancroft’s body double for The Graduate poster (1967). Ironically, she later portrayed Mrs. Robinson in a 2001 stage adaptation of the same film.

In her memoir, Gray also shared a humorous rejection letter from Glamour magazine she received in the early 1960s, which she kept as a reminder of resilience. “It kicked me from behind, and made me want to go and do something”, she said.
Though she loved motherhood, the lack of a fulfilling career frustrated her. When she finally enrolled in acting classes, her husband dismissed the idea, suggesting she wait until their children were older. At 37, she forged ahead and trained alongside younger actors. It wasn’t long before she secured her first significant role as a guest star on Marcus Welby, M.D. in 1974.

The turning point came in 1978 when Gray was cast as Sue Ellen Ewing on Dallas. Initially meant to be a recurring role for just five episodes, her performance resonated with audiences and critics alike, leading to her becoming a series regular and turning her into a star.

Dallas, set against the backdrop of family rivalry and scandal at Southfork Ranch, showcased Gray’s exceptional talent. Her chemistry with Larry Hagman was palpable, but she clarified that it stemmed from a sibling-like bond. “He was the bad big brother that I never had”, she explained. Their dynamic translated beautifully on-screen, captivating both the network executives and viewers alike.

The show broke numerous viewing records, becoming one of the most-watched television series in history. The iconic episode revealing who shot J.R. Ewing drew an estimated 80 million viewers, a record that stood until surpassed by MASH*.
For her role, Gray received two Golden Globe nominations and an Emmy nomination for Outstanding Lead Actress. After divorcing Ed Thrasher in 1983, her son Jeff pursued a career in directing and earned an Emmy nomination in 2018. Tragically, he passed away in 2020 after battling leukemia. Gray honored him on Instagram, celebrating his life and the love he shared with those around him.

Throughout her tenure on Dallas, Gray appeared in 308 episodes. Following the show’s conclusion, she continued to work in television and reprised her role as Sue Ellen in the 2012 revival of Dallas, which aired for two seasons. She received a Special Award at the 2014 USA Film Festival, further cementing her legacy.
Now, at 84, Linda Gray remains as stunning as ever. She has navigated many challenges, from her childhood struggles to her difficult marriage and the loss of her son. Through it all, she has learned to transform adversity into resilience.
We admire her strength and wish her continued success in the years to come! Feel free to share this inspiring story with your family and friends.
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