With four small children under her care, Jennifer was left a single mother after her husband, Adam, unexpectedly left when he learned she was expecting their fourth child. “One more kid to feed? Not at all! His final words as he left their trailer and filed for divorce were, “I’ve had enough!” Devastated, Jennifer found it impossible to provide for her family without Adam’s assistance, particularly given their preexisting financial struggles.
Adam ceased giving any money after the divorce, saying he was unemployed and couldn’t find work because he didn’t have a college degree. Jennifer was desperate to support her kids, and she realized she needed to get a job. While looking for work, she was consistently turned down by companies who would often point out that it was hard to hire a woman with little children. Unfazed, she continued looking for work in a nearby city, paying for a cab ride with the little cash she had while neighbors watched her kids.
When she discovered a vacancy for a housekeeping position at a nearby hotel, her perseverance paid off. She was employed right away by the HR manager, who was keen to fill roles before the hectic summer season. Jennifer went back home, thrilled to have found a job, to tell her children about her good fortune. But the daily taxi rides soon got too expensive, and she started thinking about getting a car.
Though Jennifer wasn’t sure whether she could afford it, she came across a secondhand car that appeared to be ideal for her needs. She went over to the owner, told him what had happened, and asked if he would sell the automobile for $5,000. Jeff, the owner, was moved by her narrative and agreed to the cheaper price as long as she could pay by the next day. However, because of her bad credit, Jennifer’s loan application was quickly turned down.
When Jennifer ran out of options, she made an extremely painful choice. To raise the required money, she made the decision to sell a gold chain necklace that belonged to her late mother. After she brought the necklace to a pawnshop, the value was $5500, which was sufficient to pay for the car and several other urgent necessities.
Jennifer came back to the dealership the following day with $5,000 in cash. Jeff complimented her on her purchase and grinned as he took the money. Jeff added that he had left something for her kids in the car’s trunk as she was getting ready to leave.
Before long, Jennifer’s life was consumed by work and taking care of her kids, and she forgot about Jeff’s final remarks until she found a note in the glove box. She was shocked to see the same white envelope she had used to pay for the automobile when she eventually checked the trunk, as the note had advised her to do. The whole $5,000 was there, undamaged.
Jennifer went back to the dealership to express her sincere gratitude to Jeff for his amazing gift. “The world throws challenges at you, and it’s up to you to either rise from these challenges or succumb to them,” Jeff stated with a simple smile. I think you deserve the money more than I do, and I’m proud of you for standing by your kids. Just remember to give back as well.
With tears in her eyes, Jennifer departed the dealership, knowing that Jeff’s generosity had not only reduced her financial load but also given her newfound hope in the goodness of humanity.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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